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Titlebook: Cancer Drug Resistance; Beverly A. Teicher Book 2006 Humana Press 2006 angiogenesis.cancer.cytotoxicity.drug.drug resistance.hormones.imag

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Cisplatin Resistances coexist to create a complex multifaceted dilemma, which confounds cancer treatment strategies. However, additional platinumbased agents with different spectrums of antitumor activity are entering the clinic, but it is likely that more-potent leads may be identified from among the large reservoir o
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The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumorsance, enhanced invasion, and metastasis. Results indicate that concurrent targeting of both tumor and endothelial cells may be of central importance in improving treatment responses to both radiation and chemotherapy.
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Tumor Oxygenation and Treatment Responsession. This chapter discusses recent research focused on methods of measuring tumor hypoxia accurately and extensively, with the aim of tailoring treatment on an individual patient basis. Examples of therapeutic approaches designed to exploit tumor hypoxia directly or indirectly, are discussed.
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Book 2006 and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
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Tumor Site Implantation and Animal Model Selection in Oncologypretation of result with early stage drug candidates must be carefully considered..In this chapter, we review a number of studies that support the notion that tumor implantation site represents a critical determinant for the successful and meaningful efficacy evaluation of chemotherapeutic agents.
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