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Titlebook: Calorie Restriction, Aging and Longevity; Arthur V. Everitt,Suresh I. S. Rattan,Rafael Cabo Book 2010 Springer Science+Business Media B.V.

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https://doi.org/10.1007/978-3-031-60183-5. Data from these organisms demonstrate that it is not calories per se that drives the relationship between diet and longevity, but rather the ratio of protein to non-protein energy ingested. It is argued that similar geometric analysis is required for mammalian model systems.
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Neurocomputational Models of Time Perceptionderstanding of the effects of CR on learning and memory. As the reader will discern, the hypothesis that CR is beneficial to learning and memory in senescent animals is only partially supported by the current data.
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Thomas H. Rammsayer,Stefan J. Troche restriction appears to act via discrete cellular mechanisms such as sirtuin pathways that impact cellular bioenergetics, apoptosis and other cellular functions. The liver has as a pivotal coordinating role when dietary intake is reduced, therefore many of the effects of caloric restriction are mediated by the liver.
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https://doi.org/10.1007/978-1-4615-8618-0. Also discussed are some of the possible caloric restriction-induced cellular mechanisms by which age-related vascular oxidative stress and inflammation can be delayed or reversed thereby improving cardiovascular health in the elderly.
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The Aging Liver and the Effects of Long Term Caloric Restriction restriction appears to act via discrete cellular mechanisms such as sirtuin pathways that impact cellular bioenergetics, apoptosis and other cellular functions. The liver has as a pivotal coordinating role when dietary intake is reduced, therefore many of the effects of caloric restriction are mediated by the liver.
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