Titlebook: CNS Cancer; Models, Markers, Pro Erwin G. Meir Book 2009 Humana Press 2009 CNS.Nervous System.angiogenesis.brain.brain tumor.brain tumors.c

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书目名称CNS Cancer影响因子(影响力)




书目名称CNS Cancer影响因子(影响力)学科排名




书目名称CNS Cancer网络公开度




书目名称CNS Cancer网络公开度学科排名




书目名称CNS Cancer被引频次




书目名称CNS Cancer被引频次学科排名




书目名称CNS Cancer年度引用




书目名称CNS Cancer年度引用学科排名




书目名称CNS Cancer读者反馈




书目名称CNS Cancer读者反馈学科排名

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Using Neurofibromatosis Type 1 Mouse Models to Understand Human Pediatric Low-Grade Gliomasealth Organization (WHO) grade I astrocytomas. Children with NF1 develop low-grade pilocytic astrocytomas most frequently along the anterior optic pathway with a mean age at diagnosis of 4.5 years. Recent advances in mouse genetic engineering have resulted in the generation of . mutant mice that for

CROAK

Transgenic Mouse Models of CNS Tumors: Using Genetically Engineered Murine Models to Study the Role e models or GEMs have provided a great deal of understanding in investigating the role of p21-Ras in GBM. Elevation of Ras activity is a molecular hallmark of GBM and is under intense investigation. Several animal models have been engineered to express mutant forms of Ras or aberrantly express recep

originality

-Deficient Mouse Models for High-Grade Astrocytomasssive glioma, has not greatly improved over the last few decades. Innovative new therapies based on detailed molecular mechanisms of glioma biology are highly desired. Mutation or loss of PTEN (phosphatase tensin homolog deleted on chromosome ten), a key phosphatase that antagonizes the PI3K/AKT pat

细胞膜

The , Mouse Model of Anaplastic Astrocytoma and Secondary Glioblastoma: Dissecting Genetic Susceptib subset of glioblastoma multiforme (GBM). Studies on human GBM have shown that upregulation of the Ras signaling pathway and disruption of the p53 checkpoint pathway are central to the formation of these tumors. Although much is now known about the molecular pathways altered in these tumors, they re

细胞膜

Modeling Astrocytomas in a Family of Inducible Genetically Engineered Mice: Implications for Preclinsmal patient outcomes for which few effective drugs are available. Genetically engineered mouse (GEM) models of astrocytoma represent a powerful technique for defining the molecular and genetic abnormalities that contribute to tumorigenesis. Based on the genetic aberrations observed in human astrocy

言外之意

Human Brain Tumor Cell and Tumor Tissue Transplantation Modelsresearch for many years. A major potential limitation of using the latter as a source for establishing tumor grafts is that the therapeutic response of rodent-derived cell lines can be different from those of human glioma cells, and such differences are certainly of importance to the translational r

CEDE

Transformed Human Brain Cells in Culture as a Model for Brain Tumors, however, is by nature correlative, and as a result, investigators have turned to manipulable systems in which defined genetic alterations can be sequentially introduced and monitored for effect. While much of this work involves the use of animal models, a significant and growing number of investig

针叶类的树

Rat Glioma Models for Preclinical Evaluation of Novel Therapeutic and Diagnostic Modalitiesalities. The first three tumors that we will discuss were induced by repeated injections of methylnitrosourea (MNU) to adult rats. The 9L gliosarcoma has been widely used and has provided important information relating to brain tumor biology and therapy. The T9 glioma, although not generally recogni