Titlebook: CNS Cancer; Models, Markers, Pro Erwin G. Meir Book 2009 Humana Press 2009 CNS.Nervous System.angiogenesis.brain.brain tumor.brain tumors.c

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Introduction: Narcissus and the Wounded Selfssive glioma, has not greatly improved over the last few decades. Innovative new therapies based on detailed molecular mechanisms of glioma biology are highly desired. Mutation or loss of PTEN (phosphatase tensin homolog deleted on chromosome ten), a key phosphatase that antagonizes the PI3K/AKT pat

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https://doi.org/10.1057/9781137491480 subset of glioblastoma multiforme (GBM). Studies on human GBM have shown that upregulation of the Ras signaling pathway and disruption of the p53 checkpoint pathway are central to the formation of these tumors. Although much is now known about the molecular pathways altered in these tumors, they re

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https://doi.org/10.1057/9781137491480smal patient outcomes for which few effective drugs are available. Genetically engineered mouse (GEM) models of astrocytoma represent a powerful technique for defining the molecular and genetic abnormalities that contribute to tumorigenesis. Based on the genetic aberrations observed in human astrocy

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Case Studies and Practical Advicen zebrafish. Some of the tumors in these species share many features including histopathological appearance, neuroimaging characteristics, tumor genetics, molecular targets, and biological behavior. Based on such similarities, studying the CNS tumors of dogs and mice and the genetics of neuronal neo