Titlebook: Buruli Ulcer; Mycobacterium Ulcera Gerd Pluschke,Katharina Röltgen Book‘‘‘‘‘‘‘‘ 2019 The Editor(s) (if applicable) and The Author(s) 2019 C

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The Immunology of Buruli Ulcer,rotic toxin that has shown the ability to interfere with the immune response. This poses an additional difficulty to the understanding of the immunological determinants for the outcome of infection, a fundamental step to develop better preventive or curative strategies. In this chapter, the immune r

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Buruli Ulcer in Animals and Experimental Infection Models,y occur mainly at places where no or only sparse fur is present: the ears, paws and the nose. To date such naturally infected animals have only been detected in Australia. In order to tackle specific research questions in vivo, several experimental . infection animal models have been developed, of w

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Laboratory Diagnosis of Buruli Ulcer: Challenges and Future Perspectives,ve agent, ., is incomplete. Early case detection and rapid initiation of treatment are key elements to prevent the development of large, disfiguring ulcers often associated with permanent physical disability and stigma. BU has been reported from 34 countries, with the greatest disease burden in West

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Antimicrobial Treatment of , Infection,s in their patients to be caused by tuberculosis or leprosy, when they observed numerous acid-fast bacilli in the biopsy specimens [1]. The typical duration of illness was between 1 and 2 years; treatment was essentially surgical. With the advent of chemotherapy for tuberculosis [2–4], and later for

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Transdisciplinary Research and Action to Stop Buruli Ulcer: A case Study from Philanthropy,e. With the goal to catalyse a transdisciplinary consortium bundling Buruli ulcer research into a consorted effort, the UBS Optimus Foundation engaged researchers from different disciplines and countries, with a prominent role of endemic countries and good links to national Buruli ulcer control prog