Titlebook: Buruli Ulcer; Mycobacterium Ulcera Gerd Pluschke,Katharina Röltgen Book‘‘‘‘‘‘‘‘ 2019 The Editor(s) (if applicable) and The Author(s) 2019 C

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Infection in French Guiana; Current State of Knowledge,derreported in most of the continent; or the specific environmental conditions in French Guiana represent a unique niche for the disease to appear; or a sublineage of . has established in French Guiana that has a higher virulence than other members of the ancestral lineage found in the Americas.

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Book‘‘‘‘‘‘‘‘ 2019nt of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of .Mycobacterium ulcerans..

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P. P. B. Eggermont,V. N. LaRicciaycolactones, led to a specific lineage of . causing the majority of human disease. At local scales, detailed longitudinal, comparative genomic studies of . isolates recovered from BU endemic regions have revealed patterns of pathogen spread that are providing useful new understandings around BU transmission.

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Book‘‘‘‘‘‘‘‘ 2019 in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the micr

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Buruli Ulcer in Japan,ue to Japan and potentially China. Genetic characterization of this species has begun, and the efficacy of various therapies has been analyzed. Although treatment with triple antimicrobial therapy comprising rifampicin (RFP; 450 mg/day), levofloxacin (LVFX; 500 mg/day), and clarithromycin (CAM; 800 

GEON

Population Genomics and Molecular Epidemiology of ,and in particular within Africa and Australia, the regions most affected by Buruli ulcer (BU). This chapter summarizes our current understanding of the emergence of . from a . ancestor, and describes how at least two evolutionary bottlenecks, that included acquiring the specific capability to make m