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Titlebook: Brain Damage and Repair; From Molecular Resea T. Herdegen,J. Delgado-García Book 2004 Springer Science+Business Media B.V. 2004

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The Aging Brain — the Burden of Life (?)veral brain diseases in middle, and more frequently, in old age such as stroke (brain ischemia), Parkinson’s disease and dementia of either vascular origin or sporadic Alzheimer type..Cellular and molecular mechanisms in mammalian brain during adult life and their variations in old age will be discu
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Synaptic Plasticity: Hyperexcitability and Synaptic Silencingres. Long-lasting increase or decrease of synaptic efficacy — termed long-term potentiation (LTP) and long-term depression (LTD), respectively — has been related to the establishment of memory traces. Experimental induction of both types of long-lasting changes has contributed effectively to the stu
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The Organelles, I: Mitochondrial Failure And Neurodegenerationtion of apoptosis, a program of cell death. The molecular components required for the functional activities of mitochondria are very vast and are encoded in both the nuclear and the mitochondrial genomes. Therefore, mutations and/or epigenetic factors that affect the activity of any of the gene prod
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The Organelles II: Endoplasmic Reticulum and its Overloadsynthesized membrane and secretory proteins are folded and processed in this subcellular compartment. These are strictly calcium-dependent processes that need for correct functioning a calcium activity in the range close to that of the extracellular space. Under conditions associated with ER dysfunc
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