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Titlebook: Brain Damage and Repair; From Molecular Resea T. Herdegen,J. Delgado-García Book 2004 Springer Science+Business Media B.V. 2004

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https://doi.org/10.1007/978-88-470-1060-4function in the body. After a brief historical review, the peculiar nature of neuronal size and shape are considered, together with the consequences of this for neuronal classification, connectivity, excitability, intracellular transport and vulnerability to injury. This is followed by a description
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https://doi.org/10.1007/978-88-470-1060-4ties, delivery of molecules via intra-axonal transport and support from external cellular and extracellular sources. Trauma, ischemia, toxic agents, metabolic disturbances, inflammatory conditions and inadequate axon-glial interactions result in axonal disintegration. This process is characterized b
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https://doi.org/10.1007/978-88-470-1060-4es and after acute brain insults. Neuronal apoptosis which has a crucial function for elimination of unwanted neurons in the immature nervous system, for a long time was thought to be restricted to this type of developmental cell death. In recent years however, evidence has accumulated that apoptosi
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https://doi.org/10.1007/978-88-470-1060-4synthesized membrane and secretory proteins are folded and processed in this subcellular compartment. These are strictly calcium-dependent processes that need for correct functioning a calcium activity in the range close to that of the extracellular space. Under conditions associated with ER dysfunc
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F. F. Faletra,T. Moccetti,G. Pedrazzinising. Multiple proteins involved in RNA transcription and pre-mRNA processing can interact with general transcription factors and transcriptional activators, which associate with polymerase at gene promoters. Huntington’s disease, dentatorubralpallidoluysian atrophy and five spinocerebellar ataxias
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F. F. Faletra,T. Moccetti,G. Pedrazzini process originating from enzyme catalyzed redox reactions triggered by the turnover of endogenous and exogenous substrates. Due to the high reactivity of radicals, covalent modifications of lipids, proteins and DNA are likely to occur if radicals are not trapped by scavengers such as tocopherol, as
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https://doi.org/10.1007/978-981-97-4220-2he distribution of local and long-range guidance cues. Gradients of long-range guidance cues have been associated with growth cone function for over a hundred years, but their developmental roles are still poorly understood. Here we review the developmental roles and the complex intracellular signal
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