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Titlebook: Brain Damage and Repair; From Molecular Resea T. Herdegen,J. Delgado-García Book 2004 Springer Science+Business Media B.V. 2004

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期刊全称Brain Damage and Repair
期刊简称From Molecular Resea
影响因子2023T. Herdegen,J. Delgado-García
视频video
发行地址Aims at building a novel bridge from molecular research to clinical therapy.omprehensive chapters on neurological diseases, such as M. Alzheimer, M. Parkinson, ALS, stroke or trauma, take this knowled
图书封面Titlebook: Brain Damage and Repair; From Molecular Resea T. Herdegen,J. Delgado-García Book 2004 Springer Science+Business Media B.V. 2004
影响因子.Brain Damage and Repair. aims to attract the interest of neuroscientists and clinical neurologists by building a novel bridge from molecular research to clinical therapy. This novel approach reveals the functional features of neurons and glia in the particular context of vulnerability and self-protection, intracellular properties and extracellular matrix. Arising from this platform, this volume unfolds the molecular and systemic processes underlying migration disorders, axonal injury, repair and regeneration. Comprehensive chapters on neurological diseases, such as M. Alzheimer, M. Parkinson, ALS, stroke or trauma, take this knowledge, apply it at the clinical level to provide a basis for novel therapeutic strategies. .Brain Damage and Repair. is completed with chapters on imaging techniques, viral gene transfer or legal international handling of stem cell transfer and patents of DNA/proteins.
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The Organelles II: Endoplasmic Reticulum and its Overloadfunctioning is impaired in multiple ways. These include disturbances of ER calcium homeostasis, impairment of ERAD and UPR, and insufficient proteasome functioning which triggers secondary ER dysfunction. Therapeutic interventions designed to suppress the pathological process culminating in neuronal
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Transcriptional Dysfunctions as Pathogenic Mechanism of Neurodegenerative Diseases protein diversity and determine the subcellular location, molecular interactions, or function of proteins. Neuron-specific proteins involved in RNA splicing and metabolism are affected in several neurological disorders. Defects in RNA processing proteins, such as SMN protein, may lead to the Spinal
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Formation of Radicalsn’s disease increased levels of biomarkers of oxidative and nitrosative stress have been identified in the brain. Some of which such as hydroxyalkenals and isoprostanes may even gain diagnostic value for the determination of the degree of neurodegeneration. However, scientific efforts have to be con
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Microglia and the Cerebral Defence System or disturbances in the CNS homeostasis. Deregulated or dysfunctional microglia can, on the other hand, be critical or at least instrumental in a harmful way. Excessive and chronic reaction of microglia can then fuel destructive cascades upon trauma or during inflammatory and neurodegenerative proce
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