Titlebook: Blood-Brain Barrier; Tatiana Barichello Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Neuronal progenitor c

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Beyond First-Order Truthlikeness,d consensus between TEER reported from various BBBs-on-chips, it is important to understand various factors that affect TEER. The aim of this chapter is to introduce TEER and its significance, explore the different TEER measurement protocols along with their strengths and weaknesses, and review nume

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https://doi.org/10.1007/978-94-009-4658-3stic traits of various BBB-permeable cell-penetrating peptides (CPPs), which have emerged as a potential drug delivery tool in CNS therapeutics. In this chapter, we would like to review the benefits of employing nuclear magnetic resonance (NMR) techniques toward understanding the structural, functio

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Jason H. Calhoun,Anne C. Sullivand plexus prepared from rat cerebroventricles and a conditionally immortalized rat choroid plexus epithelial cell line, TR-CSFB3 cells, are described in detail. The information obtained from these studies will help us to understand the molecular mechanisms of compound efflux transport across the BCSF

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Methods of Delivering Molecules Through the Blood-Brain Barrier for Brain Diagnostics and Therapeutthe difficulty in delivering diagnostic and therapeutic molecules across the blood-brain barrier (BBB) and into the brain. This chapter describes these and other challenges and the progress that has been made in transporting molecules into the brain. The pathways that molecules can take to cross the

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Culturing of Rodent Brain Microvascular Endothelial Cells for In Vitro Modeling of the Blood-Brain tive function, BBB regulates entry of nutrients into the central nervous system by selective transport and metabolism of blood- and brain-borne substances. Successful modeling of BBB in vitro is established since 1970s and has been used to study mechanisms of transport, cellular interaction, and gen