Titlebook: Blood-Brain Barrier; Tatiana Barichello Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Neuronal progenitor c

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Transepithelial/Transendothelial Electrical Resistance (TEER) to Measure the Integrity of Blood-Brad consensus between TEER reported from various BBBs-on-chips, it is important to understand various factors that affect TEER. The aim of this chapter is to introduce TEER and its significance, explore the different TEER measurement protocols along with their strengths and weaknesses, and review nume

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Cell-Penetrating Peptides as Theranostics Against Impaired Blood-Brain Barrier Permeability: Implicstic traits of various BBB-permeable cell-penetrating peptides (CPPs), which have emerged as a potential drug delivery tool in CNS therapeutics. In this chapter, we would like to review the benefits of employing nuclear magnetic resonance (NMR) techniques toward understanding the structural, functio

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Experimental Tools to Study the Regulation and Function of the Choroid Plexus,-cerebrospinal fluid barrier (BCSFB) in vitro models. This chapter describes these protocols aiming to attract more researchers willing to enhance the current knowledge on CP functions and the relevance of its malfunction to the central nervous system pathophysiology.

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Increasing BBB Permeability via Focused Ultrasound: Current Methods in Preclinical Research,, there is a need for improved monitoring strategies that can precisely predict resulting bio-effects. This will allow the continued development of control algorithms that can further increase the safety profile of FUS. Here we will describe two approaches to study FUS-mediated increases in BBB perm

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,Evaluation of Blood–Brain Barrier Permeability and Integrity in Juvenile Rodents: Dynamic Contrast-ssociated with reflow through ischemic tissue. We are particularly interested in the reperfusion-induced injury to the blood–brain barrier (BBB) that follows after blood flow to the ischemic brain is restored..Our goal is to provide the reader with guidelines on how to execute the tMCAo surgical pro

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https://doi.org/10.1007/978-3-319-72425-6e of potentially harmful xenobiotics, the study of the BBB in vitro is gaining momentum. As new cell culture techniques and improved in vitro technologies and biomaterials become available, in vitro modeling of the BBB is progressing rapidly. In this book chapter, we provide a detailed view and anal

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https://doi.org/10.1007/978-3-319-72425-6rived human brain microvascular endothelial cells (HBMvECs), and showing how BBB phenotype is improved in response to flow by using immunocytochemical localization of tight-junction zonula occludens-1 (ZO-1) as a reporter index. The ability of applied shear to attenuate the pro-oxidant effects of in