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Titlebook: Blood-Brain Barrier; Tatiana Barichello Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Neuronal progenitor c

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期刊全称Blood-Brain Barrier
影响因子2023Tatiana Barichello
视频video
发行地址Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
学科分类Neuromethods
图书封面Titlebook: Blood-Brain Barrier;  Tatiana Barichello Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Neuronal progenitor c
影响因子This volume focuses on experimental research with applicable models to study physiology, biochemistry, and molecular biology of the blood-brain barrier (BBB). This book is organized into six parts: Part One is an overview of the physiology of BBB; Part Two explores in vitro cell models to study the BBB; Part Three discusses techniques in vivo and ex vivo models to evaluate BBB in .Drosophila melanogaster., .Zebrafish., and rodents; Part Four looks at permeability, influx, efflux transportation, and drug delivery through the BBB; Part Five talks about various invasive and non-invasive imaging techniques to study BBB; and Part Six describes how molecular biomarkers are used to look at the integrity or dysfunction of the BBB. In .Neuromethods. series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. .Cutting-edge and thorough, .Blood-Brain Barrier. is a valuable resource to aid both novice and experienced investigators with performing experiments using new and classic translational approaches..
Pindex Book 2019
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Approximate Inference Via the EM Algorithmthe difficulty in delivering diagnostic and therapeutic molecules across the blood-brain barrier (BBB) and into the brain. This chapter describes these and other challenges and the progress that has been made in transporting molecules into the brain. The pathways that molecules can take to cross the
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An Introduction to Bayesian Inferencetive function, BBB regulates entry of nutrients into the central nervous system by selective transport and metabolism of blood- and brain-borne substances. Successful modeling of BBB in vitro is established since 1970s and has been used to study mechanisms of transport, cellular interaction, and gen
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https://doi.org/10.1007/978-3-319-72425-6e performed in vivo. However, major limitations of this approach, including limited translational significance to human patients, high cost, time, and labor to develop the appropriate model (e.g., transgenic or inbred models), have greatly favored the parallel development of in vitro models. These a
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https://doi.org/10.1007/978-3-319-72425-6ly mimic the physiological complexity of the in vivo BBB continues to be a challenge, however. To meet this challenge, in vitro BBB models have evolved significantly over the last three decades, from static monocultures to dynamic multicellular flow-based systems. In this chapter, we initially focus
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Beyond First-Order Truthlikeness, in vitro cellular barriers for transport studies. TEER measurement has advantages over traditional permeability measurements as a quick, label-free, and non-invasive method. TEER measurement has an added advantage that it can be performed in real -time if the measurement electrodes are integrated i
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