Titlebook: Blood-Brain Barrier; Tatiana Barichello Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Neuronal progenitor c

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https://doi.org/10.1007/978-94-009-4658-3bstances. This dynamic barrier, which is primarily comprised of precisely arranged, specialized endothelial cells, astrocytes, and pericytes, not only prevents the brain interstitial fluid from mixing with the components of blood but also maintains a delicate balance between central nervous system (

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The prosthetic service in the UK,lieu intérieur of the central nervous system. To elucidate the function of CPECs, in vitro primary culture is an ideal system as the choroid plexus (CP) is situated deep in the brain ventricular system in situ. This location makes detailed analysis of these cells difficult. Moreover, its highly undu

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Haim Shtarker,Mikhail Samchukovailable for this organism, . is uniquely suited to study bbb physiology and function, with high relevance for mammalian function. In this chapter we discuss targeting strategies to specifically mark and manipulate BBB cells, how to test BBB integrity, and methods to isolate single-BBB cells.

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https://doi.org/10.1007/978-3-319-18023-6the BBB is a major obstacle for drug delivery into the brain. Under pathological conditions, the integrity of the BBB is susceptible to disruption and can be broken down in severe brain diseases. Therefore, the understanding of intrinsic complexity as well as modulation of the BBB is critical to dis

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Growth Plate Injuries: An Introductionquires appropriate models and markers to demonstrate the integrity of the interface between the blood and the brain. Historically, dyes have been used to analyze the blood-brain barrier (BBB) mechanisms and for measurements of plasma volume. Despite some limitations, Evans blue is still the most com

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Pablo Wagner,John E. Herzenbergh neurologic diseases, in newborns, young adults, and the elderly, like kernicterus, multiple sclerosis, and Alzheimer’s disease. Yet, the CP still remains an overlooked organ requiring further investigation..The minute size of the CP, particularly in rodent models, increases the difficulties associ

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Jason H. Calhoun,Anne C. Sullivanng specific transport of drugs and nutrients is essential to improve our understanding of the pharmacological and physiological roles of the BRB. This will contribute to the development of novel systemic drug delivery system that will help with safer and more efficient therapy of severe retinal dise

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S. Robert Rozbruch,Reggie C. Hamdy(CNS) diseases. The use of focused ultrasound (FUS), in conjunction with circulating microbubbles, is a unique approach whereby the transcranial application of acoustic energy, focused within targeted brain areas, can be used to induce a noninvasive, transient, and targeted increase in BBB permeabil

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