Titlebook: Bleomycin: Chemical, Biochemical, and Biological Aspects; Proceedings of a joi Sidney M. Hect Conference proceedings 1979 Springer-Verlag N

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Jan Glaubitz,Daniel Rademacher,Thomas Sonar.) and the ferrous complex has been implicated as the possible active species causing bleomycin-catalyzed DNAstrand scission (.). Both cupic and ferrous ions are paramagnetic, hence proton nuclear magnetic resonance (NMR) is of limited value for the study of any of their complexes with bleomycin bec

BILK

theta-waves

,Vektorräume und lineare Abbildungen, salt added to the fermentation medium; without addition of the copper, the fermentation yield of BLM is significantly reduced. The chelated copper can be removed from BLM by precipitation with hydrogen sulfide in methanol solution. Treatment of metal-free BLM with an excess of an inorganic cupric s

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https://doi.org/10.1007/978-3-8348-9858-6ity to coordinate a variety of metals. Recently, bleomycin-metal complexes have attracted particular attention because of their interesting behavior: (i) the copper(II) complex is a metabolic form of bleomycin (2), (ii) γ-emitting metal complexes such as .CO, .Tc, and .In have been investigated as a

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Debility

https://doi.org/10.1007/978-3-658-18191-8re effective against squamous cell carcinoma, Hodgkin’s disease, and malignant lymphoma and are particularly valuable since they show no immunosuppression.. The mode of action has attracted a great deal of attention but the molecular mechanism of action is by no means clear. BLM shows interference w

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,Vektorräume und lineare Abbildungen,bited by simultaneous addition of DNA from other species (protection by competitive binding) but not by the addition of RNA. Based on the protective effect of the added DNA, the preferred DNA structure for interaction with bleomycin was determined. The results indicate that bleomycin binds preferent

Analogy

Bilineare Algebra und Geometrie,Nuclear magnetic resonance studies. suggest that the bithiazole and terminal amine moieties of the bleomycins bind to DNA; certain other functional groups of the antibiotic serve as ligands for the metal ion.. Some of the structural requirements for biological activity of bleomycin have been establi

licence

,Vektorräume und lineare Abbildungen,ezawa ... It has been established that the drug causes the release of free bases, ruptures the phosphodiester backbone, and damages the deoxyribose moiety of DNA. There are no detectable damaging effects on RNA, nor does the drug alter the ability of mRNA to direct cell-free protein synthesis. For a