Titlebook: Bleomycin: Chemical, Biochemical, and Biological Aspects; Proceedings of a joi Sidney M. Hect Conference proceedings 1979 Springer-Verlag N

Gum-Disease

脆弱带来

A Role for Iron in the Degradation of DNA by BleomycinrsS. as a copper chelate, it is used clinically as a metal-free preparation. Studies with bleomycin have suggested that its cytotoxic properties are related to effects of the compound on the physical integrity of DNA in cells. In cultures of bacterial or eukaryotic cells, a major effect of bleomycin

Recess

Contribution of the Superoxide Anion-Hydroxyl Radical Pathway to the Cleavage of DNA by Bleomycinre effective against squamous cell carcinoma, Hodgkin’s disease, and malignant lymphoma and are particularly valuable since they show no immunosuppression.. The mode of action has attracted a great deal of attention but the molecular mechanism of action is by no means clear. BLM shows interference w

省略

Interaction of Bleomycin with DNAbited by simultaneous addition of DNA from other species (protection by competitive binding) but not by the addition of RNA. Based on the protective effect of the added DNA, the preferred DNA structure for interaction with bleomycin was determined. The results indicate that bleomycin binds preferent

摇曳

爱国者

Molecular Aspects of Bleomycin-Promoted Damage of Covalently Closed Circular DNAezawa ... It has been established that the drug causes the release of free bases, ruptures the phosphodiester backbone, and damages the deoxyribose moiety of DNA. There are no detectable damaging effects on RNA, nor does the drug alter the ability of mRNA to direct cell-free protein synthesis. For a

Nonthreatening

含糊

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Detoxification

https://doi.org/10.1007/978-1-4612-6191-9Bleomycin; Pyrimidine; biochemistry; biology; cancer; cell; chemistry; synthesis

高脚酒杯

978-1-4612-6193-3Springer-Verlag New York Inc. 1979