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Titlebook: Bioinformatics of Genome Regulation and Structure II; Nikolay Kolchanov,Ralf Hofestaedt,Luciano Milanesi Book 2006 Springer-Verlag US 2006

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Key Element: Si / Schlüsselelement: Si eukaryotes. Context analysis of nucleotide sequences of experimentally defined nucleosome formation sites allows the determination of the sequence preference for nucleosome formation relying on statistical information. However, context analysis does not allow identifying the clear-cut consensus mak
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Key Element: Si / Schlüsselelement: Siites are not completely understood. Given these considerations, the relation between the nucleosome positioning and the regulation of gene expression appears of great interest. Taxon-specific nucleosome organization of the yeast and mammalian core promoters was identified. The context parameters of
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Key Element: Si / Schlüsselelement: Sies programs for analysis of RNA secondary structure. The server currently offers: solution of tasks of RNA folding and inverse folding based on the genetic algorithm; estimation of a sequence capability to form secondary structure; and an editor for interactive RNA folding with imposed constraints.
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Key Element: Si / Schlüsselelement: Sieveral different levels: microevolution of orthologous regulatory sites, changes in regulon content, evolution of interacting regulatory systems, and co-evolution of transcription factors and their binding signals. Regulatory interactions appear to be very dynamic in some cases and surprisingly stab
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Key Element: Si / Schlüsselelement: Sin; ., which produces glutamic acid at a higher temperature than .; and ., which is a well-known pathogenic bacterium. Comparative genomic studies highlighted the evolutionary mechanisms underlying various aspects of the functional differentiation of these species, such as the unique metabolic featur
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Key Element: Si / Schlüsselelement: Sit unexplained genome-level phenomenon, which is in disagreement with the neutral theory of molecular evolution (Kimura, 1983). Comparison of 7732 orthologous genes of mouse and rat confirms the previously observed correlation between the rates of substitutions in non-synonymous and synonymous nucleo
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