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Titlebook: Bioinformatics of Genome Regulation and Structure II; Nikolay Kolchanov,Ralf Hofestaedt,Luciano Milanesi Book 2006 Springer-Verlag US 2006

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Key Element: Si / Schlüsselelement: Si regions, and non-coding non-regulatory DNA exhibit different statistical patterns. We suggest capturing and measuring these patterns by the following suite of statistical tools: (1) the ‘fluffy-tail’ test, a bootstrap procedure to recognize statistically significant abundant similar words in regula
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Recognition of Coding Regions in Genome AlignmentLRs, i.e., sequences of consecutive high-scoring windows. Presumably, each QELR contains one exon. Third, we point out an exon within every QELR. All the steps have to be performed twice, for the direct and reverse complement chains independently. Finally, we compare the predictions for two chains t
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Transcription Regulatory Regions Database (TRRD): A Source of Experimentally Confirmed Data on Trans(10 045) are collected in TRRD. Of them, 37 % of regulatory units and 38 % of binding sites are related to human genes. This paper characterizes groups of experiments basing on which regulatory units and binding sites are annotated. Examples of TRRD entries are given. The database is available at ht
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VMM: A Variable Memory Markov Model Prediction of Nucleosome Formation Siteskov model) computes the nucleosome formation potential for genomic DNA sequences of arbitrary lengths, including the short transcription factor binding sites. The VMM is publicly available at .
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New Methods to Infer DNA Function from Sequence Informationze of the sliding window and hence avoids averaging. The application of our methods to several annotated data sets from six eukaryotic species enables a clear separation of coding, regulatory, and non-coding non-regulatory DNA. We propose that established computational methods complemented by our ne
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