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Titlebook: Biochemistry of Arachidonic Acid Metabolism; William E. M. Lands Book 1985 Martinus Nijhoff Publishing, Boston 1985 Lipid.Nucleotide.bioch

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Ausgangslage und Fragestellung,rstanding of the role of radiation in malignancy. This is particularly so with respect to the production of prostacyclin (PGI.) which is a potent antiaggregatory substance and which may act to inhibit metastasis via the circulatory system (1).
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Bilanz- und steuerrechtliche Probleme,enes C., D., E.) and potent chemotactic actions (leukotriene B.) (3,4). Lysophosphatides have a wide range of biological activities including tumoricidal effects (5,6) and have also been implicated in several pathological states (7,8). Some lysophosphatides are also the precursors of 1-O-alky1-2-sn-
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https://doi.org/10.1007/978-3-322-87557-0, etc. Usually the HETEs are the predominant lipoxygenase product. Several reports indicate that both 11- and 15-HETE can also be formed via the lipoxygenase activity of the cyclooxygenase enzyme (1). The major hydroxy fatty acid produced by the cyclooxygenase pathway is 12-hydroxyheptadecatrienoic
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Grundlegendes zur Preisobergrenzenbestimmungoproteins (or glycoproteins and structural macromolecules) followed by metabolic events of one cell that can turn on or off an activation of neighbouring cells. In this respect, autacoids (e.g., icosanoids) may provide valuable clues for cell-cell signalling.
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Lipoxygenase Mechanisms,r precursor of eicosanoids in mammalian tissues. These two acids appear to share a qualitatively similar overall reaction mechanism, but they have quantitatively different kinetic constants. There has been a tendency for researchers to use 18:2 when studying plant lipoxygenases and 20:4 with animal
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Enzymes Synthesizing and Metabolizing Prostanoids,earrangement of the oxygen bond brings about isomeriza-tion of PGH.(9,11-endoperoxy) to PGD.(9-hydroxy-11-keto), PGE.(9-keto-11-hydroxy), PGI.(6,9-epoxy) and TXA.(9,11-epoxy in oxetane-oxane structure). Each stereospecific reaction is catalyzed by a specific enzyme.
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