Titlebook: Approaching Complex Diseases; Network-Based Pharma Mariano Bizzarri Book 2020 Springer Nature Switzerland AG 2020 Efficiency of multi-targe

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Josef König,Wolfgang Dorda,Gabriele Erharting a number of prominent aspects of malignancy. Theoretical models have established a useful theoretical framework able to explain insights into the complex interactions taking place between cancer cells and morphogenetic fields, nevertheless a large research effort must be carried out in order to

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https://doi.org/10.1007/978-3-8350-9487-1vels in non-pineal cells do not exhibit a circadian rhythm and do not depend on circulating melatonin concentrations although when animals are treated with exogenous melatonin it is taken up by presumably all cells. Mitochondria are the presumed site of melatonin synthesis in all cells; the enzymati

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https://doi.org/10.1007/978-3-8350-9487-1e recently therapeutic antibodies, natural products always hold great importance to fight cancer. . alkaloids, camptothecin derivatives, taxanes, epipodophyllotoxins, etc. are prominent examples for the success of phytochemicals and their derivatives in clinical oncology during the past decades. The

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https://doi.org/10.1007/978-3-8350-9487-1The complex synergistic interactions of CHM components in pharmacokinetics studies and biological networks are also discussed. Despite some of the scientific reports supporting the synergistic effects of multi-herbal and/or herb-drug combinations, the level of evidence remains low particularly in te

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Book 2020 selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biol

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Revisiting the Concept of Human Disease,eoretically and methodologically, is no longer tenable. We propose herein a comprehensive model able in capturing the complexity on which the disease relies, thus recognizing a different spatially (multi-level) and timely distributed target array. Moreover, given that a disease is properly a dynamic

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