Titlebook: Approaching Complex Diseases; Network-Based Pharma Mariano Bizzarri Book 2020 Springer Nature Switzerland AG 2020 Efficiency of multi-targe

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Multitarget Activities of Inositol and Inositol Hexakisphosphate,udies. However, the most striking is their consistent and reproducible anticancer effect, actively investigated and demonstrated in various experimental models during the last decades. Key molecular targets for cancer are PI3K/Akt, MAPK, PKC, AP-1 and NF-κB. Reduced burden of chemotherapy side-effec

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Synergistic Effects of Chinese Herbal Medicine and Biological Networks,wo or more medicinal herbs for the prevention and treatment of various diseases since antiquity. The key mechanisms of action of CHM for the systematic management of many diseases largely rely on the concept of synergy to reach an optimal clinical outcome with minimal side effects. With the developm

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Overcoming Antibiotic Resistance: New Perspectives,cal treatments, reduced antimicrobial options, and high mortality rates. Following the Infectious Diseases Society of America (IDSA) initiative to develop 10 new antibacterials within 2020, new molecules are finally available to address the need of active options against multidrug-resistant Gram-neg

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Darstellung der empirischen Untersuchung,and temporal scales (from genes to tissues) in order to fully understand cancer. In this chapter we present an overview of some recent developments in the multiscale mathematical modelling of cancer at each of the three scales and give discuss how this might be used to provide more targeted and pati

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https://doi.org/10.1007/978-3-7091-6891-2heir functional programming. Here, we discuss modern immunotherapeutic approaches of targeting tumor-infiltrating macrophages including inhibition of the recruitment of monocytes to the tumor, activation of apoptosis in macrophages, repolarization, based on the inhibition of pro-tumor activity or st