Titlebook: Approaching Complex Diseases; Network-Based Pharma Mariano Bizzarri Book 2020 Springer Nature Switzerland AG 2020 Efficiency of multi-targe

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Big Data, Personalized Medicine and Network Pharmacology: Beyond the Current Paradigms,ecognition that the crisis stemmed from an acritical (and sometimes dull) application of statistical methods to the experimental results is the basis for re- examine the quantitative approaches to biology. Here we give a proof-of-concept of how the prophetic statements made by Weaver (one of the fat

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Multiscale Modelling of Cancer: Micro-, Meso- and Macro-scales of Growth and Spread, one of the leading causes of morbidity and mortality across the globe, with around 14 million new cases in 2012, and this figure is set to rise over the next 20 years. The latest statistics from the World Health Organisation show that there were 8.8 million deaths from cancer in 2015. While treatme

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Precision Oncology vs Phenotypic Approaches in the Management of Cancer: A Case for the Postmitotic of the type of cancer. PO therapy is designed to inhibit the effects of putative oncogenic mutations that supposedly drive tumorigenesis, but this approach has only improved the clinical outcomes of a picked minority of patients, as PO-based treatments almost universally fail to eradicate the tumor

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,Migrastatics – Anti-metastatic Drugs Targeting Cancer Cell Invasion,tastatic activity of tumor cells rather than their proliferative ability. Therefore, the treatment of solid tumors should be supplemented with drugs that suppress the ability of tumor cells to invade through the surrounding extracellular matrix and form secondary tumors. During invasion, metastatic

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Critical Steps in Epithelial-Mesenchymal Transition as Target for Cancer Treatment,o abrogate cancer progression. Herein, we aimed to systematize the information regarding steps of EMT that can be druggable and potential therapeutics that can be used to suppress epithelial-mesenchymal plasticity. EMT can be targeted through its suppression or reversal in cancer cells directly. Des

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,Targeting the Tumor-Associated Macrophages for ‘Normalizing’ Cancer,any cancers, including breast cancer, gastric cancer, esophageal cancer, lung cancer, cervical and ovarian cancers, melanoma and others. As macrophages are involved in many steps of cancer development such as primary tumor growth, angiogenesis and lymphangiogenesis, invasion and metastasis, suppress

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Trabectedin, a Drug Acting on Both Cancer Cells and the Tumor Microenvironment, TME establish a complex relationship with cancer cells and may strongly influence disease progression. However, myeloid cells infiltrating tumor tissues promote, rather than stop, cancer progression. Tumor-Associated Macrophages (TAMs) are abundantly present at the TME and here they trigger and per

Junction

Advances in Characterizing Recently-Identified Molecular Actions of Melatonin: Clinical Implicationunder control of the light:dark cycle. Besides its regulatory pathway involving ganglion cells in the retina, the neural connections between the eyes and the pineal gland include the master circadian clock, the suprachiasmatic nuclei, and the central and peripheral nervous systems. Since pineal mela