Titlebook: Approaching Complex Diseases; Network-Based Pharma Mariano Bizzarri Book 2020 Springer Nature Switzerland AG 2020 Efficiency of multi-targe

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Approaching Complex Diseases978-3-030-32857-3Series ISSN 2661-8915 Series E-ISSN 2661-8923

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https://doi.org/10.1007/978-3-030-32857-3Efficiency of multi-target drugs; Failing drug discovery; Failure of current medical treatments; Medica

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Brain-Imaging

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Revisiting the Concept of Human Disease, outbreak of a disease, as they are habitually centered on an integrated representation of the cell biochemical and genetic pathways, and, as such, they discard the contribution of non-genetic factors and microenvironmental constraints. Thereby, since the eighties, the agenda of pharmacology discove

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Dynamical Aspects of Pharmacokinetic/Pharmacodynamic & Quantitative Systems Pharmacology Models,al studies in the field of systems biomedicine. In human physiology, complex phenomena such as heart rate variability are often associated with the maintenance of homeostasis, whereas loss of complexity is perceived as indication of pathology. In pharmacology, the response of a physiological system

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The Efficiency of Multi-target Drugs: A Network Approach,ons, less prone to drug resistance phenomena. They thus seem particularly valuable in the fields of complex disorders and infectious diseases. We discuss the generalities of tailored multi-target drug design, including target combination choice, optimization of potency ratio to the different targets

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Mining Complex Biomedical Literature for Actionable Knowledge on Rare Diseases,ical strategies to derive knowledge from data using labor intensive, inefficient, and costly practices. Complicating the task of data analysis even further, a lot of useful information about drug activities has been historically described in publications and scientific reports in .. This naturally r