Titlebook: Apoptosis in Immunology; Guido Kroemer,Carlos Martinez-A. Book 1995 The Editor(s) (if applicable) and The Author(s), under exclusive licen

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,L’approssimazione di strato limite,al. 1983) and despite an extensive knowledge of the molecular characteristics of this virus, one of the main questions is still not answered: what causes the immune system collapse in HIV infection? Indeed the hallmark of AIDS is the progressive disappearance of CD4. helper T lymphocytes which, in a

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,Le proprietà rotazionali del flusso, several organs, including CD4. T cells in the immune system, hematopoietic progenitors in the bone marrow and neurons in the brain (. et al. 1991; . 1988, 1993; . 1993b). In the immune system, cell dysfunction is obseved before cell depletion is detected. These qualitative defects are characterized

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Roberto Grassi,Giovanni Pinto,Alfredo Sianir to become activated upon antigenic stimulation. Second, T cell activation may have rather disparate consequences, T lymphocytes may become productively activated to proliferate, differentiate or exert an effector function. Alternatively, they can become activated in an abortive or aberrant fashion

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978-3-642-79439-1The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE

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Cenni sulla dinamica della turbolenza,active thymocytes, selection of B lymphocytes within the germinal centres, development of memory T cells and killing of target cells by activated cytotoxic T lymphocytes (. et al. 1989; . et al. 1991; . 1991; . et al. 1989; . et al. 1993).

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Antonio Rotondo,Massimo Vallefuocoes have demonstrated that T cells from HIV-infected individuals indeed die upon culture due to apoptosis. Here we discuss the data and give our view on the different hypotheses proposed regarding the mechanism of this type of cell death.