| 期刊全称 | Apoptosis in Immunology | | 影响因子2023 | Guido Kroemer,Carlos Martinez-A. | | 视频video | | | 学科分类 | Current Topics in Microbiology and Immunology | | 图书封面 |  | | 影响因子 | In any movement of their life, immune cells, especially T and B lymphocytes, are confronted with an essential choice: to continue their existence or to commit a sort of metabolic suicide that is referred to as apoptosis or programmed cell death. In contrast to most philosophers, lymphocytes and their precursors are constantly susceptible to suicide, and it even appears that the usual cause of T or B cell elimination is suicide rather than death from natural causes, accidents or murder. This book provides a vast overview of lymphocytes suicide: external triggers and internal motives leading to suicidal impulses, accomplices in self-destruction, weapons implicated in self-execution, removal of dead bodies and pharmacological prevention of suicide. Most of the chapters in this book are devoted to the physiology of apoptosis. The goal is to unmask the external triggers of apoptosis, unravel the signal transduction pro cesses involved therein and describe the role of oncogenes, "death genes" and effector molecules in the apoptotic cas cade. The remaining chapters deal with the pathophysiologi cal aspects of lymphocyte apoptosis, namely, as a host contribution to HIV-induced lymphopen | | Pindex | Book 1995 |
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发表于 2025-3-21 19:53:10
