Titlebook: Antiarrhythmic Drugs; Mechanisms of Antiar Günter Breithardt,Martin Borggrefe,Gerhard Hindric Book 1995 Springer-Verlag Berlin Heidelberg 1

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Sodium Channel Blockade as an Antiarrhythmic Mechanismsthetic-class drugs are the most widely prescribed antiarrhythmic agents. They exert their antiarrhythmic effect by blockade of the inward sodium current [1]. The adverse impact of drug treatment on survival of patients in Cardiac Arrhythmia Suppression Trial and in patients with atrial fibrillation

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Molecular Biology and Ion Channel Biophysics: Their Role in Rational Pharmacological Antiarrhythmic in the sophistication of the basic research tools available to study the heart and its electrical activity. First, the introduction of the patch clamp technique (Hamill et al. 1981) made it relatively easy to record membrane currents in single cardiac myocytes from a variety of species, without conc

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Management of Patients with Sustained Ventricular Tachyarrhythmias: Different Clinical Studies, Difftime of sudden death, approximately 80 % of deaths are due to ventricular tachyarrhythmias [1–3]. In addition, approximately 3–6% of postmyocardial infarction patients develop monomorphic ventricular tachycardia that does not lead to cardiac arrest. Thus, overall, approximately 400 000 patients each

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