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Titlebook: Antiarrhythmic Drugs; Mechanisms of Antiar Günter Breithardt,Martin Borggrefe,Gerhard Hindric Book 1995 Springer-Verlag Berlin Heidelberg 1

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发表于 2025-3-21 16:06:36 | 显示全部楼层 |阅读模式
期刊全称Antiarrhythmic Drugs
期刊简称Mechanisms of Antiar
影响因子2023Günter Breithardt,Martin Borggrefe,Gerhard Hindric
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图书封面Titlebook: Antiarrhythmic Drugs; Mechanisms of Antiar Günter Breithardt,Martin Borggrefe,Gerhard Hindric Book 1995 Springer-Verlag Berlin Heidelberg 1
影响因子The past 10 years have seen a remarkable change in the approach to cardiac arrhythmias, from a position of confidence and a feeling of well-being about pharmacological treatment to a situation in which there is now marked uncertainty and general apprehension about the role of antiarrhythmic drugs. Until relatively recently the prevailing concept in antiarrhythmic therapy was that arrhythmias could be controlled by drugs which slowed conduction or suppressed automaticity, goals well served by the sodium channel-blocking drugs and glycosides. Drug re­ search was based largely on the development of agents mimicking those already available, but with greater efficacy, fewer side effects or a more favourable phar­ macokinetic profile. The CAST trial stands out as a landmark in the evolution of arrhytmia manage­ ment; rarely has a single trial had such a profound impact not only on clinical prac­ tice, but also on the whole approach of those involved in the research, development and regulation of antiarrhythmic drugs. The results of the CAST trial, designed to redress the shortcomings of earlier trials which had failed to demonstrate the anticipated improvement in mortality post-myocardia
Pindex Book 1995
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发表于 2025-3-21 22:39:13 | 显示全部楼层
Die Physiologie der peripheren Nerven I type [2]. The fundamental question that should be answered is whether better results may be expected from the new approach of using drugs prolonging the action potential duration. Is this new hope justified?
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being about pharmacological treatment to a situation in which there is now marked uncertainty and general apprehension about the role of antiarrhythmic drugs. Until relatively recently the prevailing concept in antiarrhythmic therapy was that arrhythmias could be controlled by drugs which slowed con
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发表于 2025-3-22 10:21:07 | 显示全部楼层
Jan Niklas Collet,Jan-Hendrik Herbstles at those site(s), may be an important tool to understand variability in response to antiarrhythmic drug therapy. Such understanding, in turn, may lead to an improved ability to predict patients at risk for serious adverse events, as well as to adjust doses to maximize efficacy.
发表于 2025-3-22 14:54:45 | 显示全部楼层
Interaction of Transient Ischemia with Antiarrhythmic Drugsic reflexes, as well as direct damage to the cell membrane, its constituent channels, pumps and gap junctions, and the supporting collagen matrix. Preexisting scarring due to myocardial infarction, cardiac hypertrophy, congestive heart failure, pulmonary disease and the like may contribute to the arrhythmogenic potential of transient ischemia.
发表于 2025-3-22 18:50:52 | 显示全部楼层
The Study of Pharmacokinetics and Pharmacodynamics as a Tool for Understanding Mechanisms of Antiarrles at those site(s), may be an important tool to understand variability in response to antiarrhythmic drug therapy. Such understanding, in turn, may lead to an improved ability to predict patients at risk for serious adverse events, as well as to adjust doses to maximize efficacy.
发表于 2025-3-23 00:37:55 | 显示全部楼层
Pharmacology of T and L Type Ca2+ Channels in Cardiac Tissueture describing the pharmacology of these two cardiac Ca channels is limited, particularly in reference to the pharmacology of the T type channel. Therefore, the emphasis here is to discuss the known pharmacology of both channels with particular attention to the T type Ca channel.
发表于 2025-3-23 03:38:00 | 显示全部楼层
A Shift from Class I to Class III Drugs in the Medical Treatment of Arrhythmias: Wishful Thinking? I type [2]. The fundamental question that should be answered is whether better results may be expected from the new approach of using drugs prolonging the action potential duration. Is this new hope justified?
发表于 2025-3-23 07:33:27 | 显示全部楼层
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