Titlebook: Annual Update in Intensive Care and Emergency Medicine 2022; Jean-Louis Vincent Book 2022 The Editor(s) (if applicable) and The Author(s),

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https://doi.org/10.1007/978-1-349-02071-3 host immune response at the cellular level, and the potential and challenges of mitochondria-targeted therapies in restoring immune homeostasis in critically ill patients. We also discuss the current available diagnostic tools or biomarkers for assessing the mitochondrial metabolism in patients, wh

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Klaus Mathis MA in Economics,Deborah Shannonrobic glycolysis, causing energy depletion in the cells. Hyperoxia has direct toxic effects on the airways and lungs. Hyperoxemia in the cells and the mitochondria stimulates production of reactive oxygen species, which can cause cellular and organ injury. The results of studies on the effects of li

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Klaus Mathis MA in Economics,Deborah Shannong formulations could potentially achieve higher local drug concentrations and improve clinical outcomes with limited systemic adverse effects. Various nebulized therapeutic agents are currently undergoing clinical trials. Barriers affecting safe and effective nebulized therapies should be addressed

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Klaus Mathis MA in Economics,Deborah Shannonhan an abrupt increase in attenuating lung injury; nevertheless, an even more gradual increase did not prevent lung injury, suggesting the concept that VILI relates to repetitive cycling above a strain-injury level. In this chapter, we highlight pre-clinical and clinical evidence showing that slowin

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Magdalena Kapelko,Alfons Oude Lansinktective. Assessment of potential parenchymal injury must take into account stress and strain as the real physical quantities acting on the lung structures. Moreover, the lack of information regarding regional lung mechanics and deformation at the acinar level is likely the main determinant of these

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