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Titlebook: Annual Update in Intensive Care and Emergency Medicine 2022; Jean-Louis Vincent Book 2022 The Editor(s) (if applicable) and The Author(s),

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Hit Early: Blocking Interleukin-1 in the Treatment of COVID-19 Pneumoniatratified randomization into treatment with standard-of-care and placebo or standard-of-care and anakinra. Treatment with anakinra showed 64% patient benefit toward less severe strata of the 11-point WHO Clinical Progression Scale by day 28. Progression into severe respiratory failure was prevented
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Tidal Volume Challenge Test: Expanding Possibilitiesnous pressure and pulmonary artery occlusion pressure to predict fluid responsiveness. These dynamic tests, other than PLR, depend on heart-lung interactions that have some limitations for predicting fluid responsiveness, the most common being mechanical ventilation using low tidal volume. Among the
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Fluid Management in COVID-19 ICU Patientsnce of dynamic tests of fluid responsiveness and provides valuable measures of pulmonary edema and of lung capillary leakage. This allows the benefit/risk ratio of fluid infusion to be assessed in a personalized fashion.
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Electrolytes in the ICUrrow normal ranges and lead to new subsequent iatrogenic electrolyte abnormalities. The current chapter summarizes the (patho)physiology of electrolyte changes, with special attention to the interplay between different electrolytes. Additionally, we review the available evidence on the management of
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