Titlebook: Animal Models of Human Birth Defects; Aimin Liu Book 2020 Springer Nature Singapore Pte Ltd. 2020 Human birth defects.Animal model.Forward

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Vikram Dayal,Anantha Duraiappah,Nandan Nawnes of cardiac development and have been used to create cardiac disease models. In this chapter we examine the unique toolset available to zebrafish researchers and how those tools are used to interrogate the genetic and environmental contributions to CHDs.

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Inertia

Mouse Models of Congenital Kidney Anomalies,as an excellent resource to identify the genetic bases of human kidney defects and have led to significantly improved diagnostics. Furthermore, genetic data from human CAKUT studies have also revealed novel genes regulating kidney differentiation.

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Animal Models for Understanding Human Skeletal Defects,pmental processes in laboratory animals will be a focus of discussion. This chapter will also highlight how current genome editing technologies can be applied to model various perturbations of human chromatin structure in laboratory animals.

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Using Zebrafish to Analyze the Genetic and Environmental Etiologies of Congenital Heart Defects,es of cardiac development and have been used to create cardiac disease models. In this chapter we examine the unique toolset available to zebrafish researchers and how those tools are used to interrogate the genetic and environmental contributions to CHDs.

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https://doi.org/10.1007/978-981-15-2389-2Human birth defects; Animal model; Forward and reverse genetics; Modelling diseases; Infectious disease

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978-981-15-2391-5Springer Nature Singapore Pte Ltd. 2020

Density

D. Michael Stoddart (Lecturer in Zoology)l birth defects. The appeal of mice for these experimental studies stems from the similarities between the physiology, anatomy, and reproduction of these small mammals with our own, but it is also based on a number of practical reasons: mice are easy to maintain in a laboratory environment, are incr

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Population processes in small mammals, as neurulation. Neural tube defects (NTDs) occur when neurulation fails and are among the most common structural birth defects in humans. The frequency of NTDs varies greatly anywhere from 0.5 to 10 in 1000 live births, depending on the genetic background of the population, as well as a variety of

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https://doi.org/10.1007/978-90-481-3138-9te blood sugar levels and enzyme secretion from the exocrine acinar cells to facilitate food digestion. These pancreatic functions are essential for life; therefore, preserving pancreatic function is of utmost importance. Pancreas dysfunction can arise either from developmental disorders or adult on