Titlebook: An Introduction to Toxicology; Philip C. Burcham Textbook 2014 Springer-Verlag London 2014 Apoptosis.carcinogen.epidemiology.organ.tobacco

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ext.The author is an academic researcher with extensive teac.This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest

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Second Opinion bei Instabilitätsomarthrose electrophile. Alcohol also undergoes nonoxidative metabolism to form such conjugative metabolites as ethyl-glucuronide, ethyl-sulfate and fatty acid ethyl esters. These metabolites find growing use as biomarkers of alcohol intake and appear especially useful during the diagnosis of foetal alcohol syndrome.

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Core Concepts in Toxicology,ctions between chemicals in complex ‘real-world’ exposure scenarios involving simultaneous exposure to more than one substance is also considered. The role of lifestyle factors in shaping individual susceptibility to chemical toxicity is also highlighted, as is the timing of the manifestation of toxicity following toxicant exposure.

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Target-Organ Toxicity: Liver and Kidney,ty, while also surveying typical toxic responses in these organs (e.g. steatosis, fibrosis, cancer). The diverse mechanisms underlying excretory organ toxicity are illustrated for such classic toxicants as azidothymidine, carbon tetrachloride, paracetamol, troglitazone, cylindrospermopsin and trichloroethylene.

Small-Intestine

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978-1-4471-7256-7Springer-Verlag London 2014