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Titlebook: Advances in Research on Neurodegeneration; 3 & 4 Y. Mizuno,M. B. H. Youdim (Faculty of Medicine),P. Conference proceedings 1997 Springer-Ve

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S. A. Soman,S. A. Khaparde,Shubha Pandit model, the activity of calcineurin (which is regulated by the concentration of cytosolic calcium ions) counterbalances the activity of the “D-1 cascade”. The combined activity of the “D-1 cascade” and calcineurin can regulate the activity of calcium- and calmodulin-dependent protein kinase II.
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S. A. Soman,S. A. Khaparde,Shubha Pandits not clear how the expression of a particular HLA-class II gene translates into susceptibility to develop an organ-specific autoimmune disease. Potential explanations how this could occurr will be discussed.
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Possible role of the cholinergic system and disease models,re small and inconsistent. This may be partly due to unfavorable pharmacokinetics and dose-limiting side effects of existing drugs. Newer, brain specific acetylcholinesterase inhibitors and Ml muscarinic agonists with a lower incidence of unwanted effects are currently being evaluated.
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