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Titlebook: Advances in Research on Neurodegeneration; 3 & 4 Y. Mizuno,M. B. H. Youdim (Faculty of Medicine),P. Conference proceedings 1997 Springer-Ve

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Role of interferons in demyelinating disease, history of multiple sclerosis (MS). The drug, injected subcutaneously every other day, reduced the frequency of relapses and the expansion of central white matter pathology as measured by MRI. Twelve previous interferon trials in MS, employing a variety of interferon preparations, doses and routes
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Role of interferons in demyelinating diseases, approval of the agent revealed a significant lessening both in disease activity and in accumulating burden of disease in IFNβ-1b-treated patients compared to placebo-treated controls..The mechanism by which IFNβ-1b exerts its beneficial effect in multiple sclerosis is unknown. T suppressor cell fun
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Molecular heterogeneity of neurotransporters: implications for neurodegeneration,al of neurotransmitters from the synaptic cleft or represent intracellular transport systems that concentrate neurotransmitters in synaptic vesicles. They comprise three subgroups, Na./Cl.- or Na./K.-dependent cell surface transporters and H.-dependent transporters associated with synaptic vesicles.
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Central nervous system cytokines and their relevance for neurotoxicity and apoptosis,and brain vascular cells. In the brain, cytokines can be neuroprotective or they can contribute to neurodegeneration. The role of cytokines in the regulation of normal and abnormal brain function represents a rapidly growing frontier in neuroscience. Cytokines are pleiotropic and redundant, and they
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,Genetics of multiple sclerosis — how could disease-associated HLA-types contribute to pathogenesis?ease which is probably triggered by exogenous events, e.g. infectious agents, in susceptible individuals. Population, family and twin studies indicate that genetic factors and most likely several genes are associated with disease, but it is clear from the concordance rates of identical twins (25–30%
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