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Titlebook: A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment; Natàlia Garcia-Reyero,Cheryl A. Murphy Book 2018 Spr

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Xingmin Gao,Feng Qiu,Jinhong Xurative phylogenetic approach to ecotoxicological testing, seeking to discover the evolutionary origins and distribution of toxicity pathways across the internal branches of the animal phylogeny. Comparative –omics data from cellular and developmental studies suggest a high degree of conservation in
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Haiping Luo,Zhaopeng Yu,Jingyi Zhoul review studies in which behavioral phenotypes and neurophysiological outcomes have been anchored to specific molecular initiating events induced by a chemical exposure. Although the study of the genetic and physiological basis of behavior is still nascent, there are many noteworthy studies that ha
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Ruoyu Zhong,Wen Tang,Zhigui Guanry framework, and how to use AOPs to drive regulatory decision-making processes. In this chapter, an overview of major omics is provided that includes recent advances and describes the potential application of omics data to the development of AOPS while defining some of the challenges associated wit
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Yiming Yuan,Chunhong Sheng,Ping LvT data (e.g., transcriptomic data) with traditional toxicology information spanning a broad chemical and biological space, computationally predicted AOPs can be rapidly generated to help accelerate the curation of AOPs. AOPs are chemical agnostic thereby allowing a single AOP to be coupled with in v
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