Titlebook: A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment; Natàlia Garcia-Reyero,Cheryl A. Murphy Book 2018 Spr

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978-3-030-09758-5Springer International Publishing AG 2018

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Current Chinese Economic Report Seriesd hormone pathways, and is one of the only regulatory programs designed around a mode of action framework. A variety of biological systems affect apical endpoints used in regulatory risk assessments and without mechanistic data, endocrine disruption cannot be determined. When the EDSP was developed

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Current Chinese Economic Report Seriesre more cost-efficient compared to tests using adult fish while maintaining the physiological relevance of a vertebrate whole-organism test system. Ethical considerations are also a driver for the use of fish embryos since they are considered alternative testing models during the early stages of dev

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Xingmin Gao,Feng Qiu,Jinhong Xull be required to construct AOPs for exposures to different chemical groups making sure that we have enough representation of different test species to adequately cover the tree of life. This should include plants, which have not yet received sufficient attention from the AOP community. In this chap