Titlebook: A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment; Natàlia Garcia-Reyero,Cheryl A. Murphy Book 2018 Spr

MERIT

Haiping Luo,Zhaopeng Yu,Jingyi Zhou, physiological, and environmental stimuli, in the development of Adverse Outcome Pathway (AOP) models. In recent years, zebrafish have been extensively investigated for their potential as a model organism in behavioral toxicology due to their low maintenance cost and similarities with rodent behavi

不安

Ruoyu Zhong,Wen Tang,Zhigui Guan and when considered in the context of the adverse outcome pathway (AOP) framework. Omics data provide individual snapshots of gene expression, protein expression and metabolite activity. When integrated, these individual snapshots yield deep biological insights. Omics can provide mechanistic inform

essential-fats

CAMEO

同义联想法

Yiming Yuan,Chunhong Sheng,Ping Lvhroughout (HT) in vitro dose response data and in vivo biological outcomes. However, AOP development has also been met with challenges of its own, such as the time, effort, and expertise necessary to achieve a scientifically sound construct able to support ecotoxicology and human health risk assessm

严重伤害

Limerick

https://doi.org/10.1007/978-981-99-6667-7ed to inform ecological risk assessments come primarily from tests on individual organisms or from suborganismal studies, indicating a disconnect between primary data and protection goals. We know how to relate individual responses to population dynamics using individual-based models, and there are

Obverse

lymphedema

Yiming Yuan,Hai Xie,Mengdie Chenan contain up to 250 different contaminants and has been linked to reproductive impairment in fish. We used data from an in vitro study that characterized the potential neurochemical effects of pulp and paper mill effluent, to model vitellogenin production after exposure to different effluent fracti

检查

https://doi.org/10.1007/978-981-13-9837-7 recent years promote the large-scale use of mechanistic information, organized in the form of pathways at different levels of biological organization as a basis to underpin a dramatic change in the way chemical assessment is performed. As a result, there now exist international collaborations to de