Overview: This book constitutes the proceedings of the 15th International Conference on Algorithms and Computation, WALCOM 2021, which was planned to take place in Yangon, Myanmar in February/March 2021. The conference changed to an online format due to the COVID-19 pandemic. .The 24 full papers included in this volume were carefully reviewed and selected from a total of 60 submissions. They cover diverse.areas of algorithms and computation, such as approximation algorithms, algorithmic graph theory and combinatorics, combinatorial algorithms, combinatorial optimization, computational biology,
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