Overview: The discovery of BLy..S may lead to therapies for several diseases that involve B cells, including immune deficiencies, autoimmune disease and B cell tumors.Includes supplementary material: Discovery of the BLyS (also known as BAFF) family of ligands and receptors has yielded a paradigm shift in our view of B-lymphocyte selection, survival, activation, and homeostasis. Previously, the B-cell antigen receptor (BCR) was viewed as the sole mediator of these parameters, in which BCR signals were not only dominant but were also linearly related to consequent outcomes. However, appreciatin
|