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Titlebook: BLyS Ligands and Receptors; Michael P. Cancro Book 2010 Humana Press 2010 Antigen.autoimmunity.diseases.pathogenesis.pathophysiology.physi

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Role of BAFF and APRIL in Antibody Production and Diversification,innate immune cells and stromal cells and are upregulated in response to various danger signals. By bindings to their receptors and signaling for the activation of NF-κB, they regulate multiple aspects of T cell-dependent and -independent antibody responses including B-cell survival, activation, cla
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Signal Transduction by Receptors for BAFF and APRIL,ascades responsible for B-cell homeostasis. Transmitting these stimuli to the intracellular milieu are the receptors B-cell maturation antigen (BCMA), transmembrane activator and CAML interactor (TACI), and BAFF receptor (BAFFR). While evidence for the activation of several nuclear-independent pathw
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The Role of BAFF and APRIL in Regulating Human B-Cell Behaviour: Implications for Disease PathogeneAFF and APRIL are members of the TNF superfamily of cytokines and have been identified as critical regulators of B-cell development and differentiation. Defects in the production of BAFF and APRIL, and/or expression of their receptors, have been associated with a diverse array of human diseases char
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Tipping the Scales of Survival: The Role of BLyS in B-Cell Malignancies,buting mechanistic details underlying transformation events are not yet known. It is clear, however, that dysregulation of the balance between cell proliferation and programmed cell death is a central feature. While many factors have been shown to regulate the normal balance of B-cell growth and apo
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