Titlebook: Use of Mechanistic Information in Risk Assessment; Proceedings of the 1 Hermann M. Bolt,Björn Hellman,Lennart Dencker Conference proceeding

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Effects of Toxic Metal Pollutants on the Ecology of the Baltic Seang for such effects has deserved increasing attention in monitoring and in related scientific investigations (IOC 1988, 1990). In relation to inputs of nutrients, plastic litter and persistent organic chemicals, the contamination of the ocean and its marginal seas by heavy metals is either classifie

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Effects Of Persistent Organic Pollutants On Biota in the Baltic Seapogenic substances in biota were correlated to decreasing populations of many fish feeding species (Hook and Johnels 1972, Sandegren et al. 1980, Olsson 1963, Heiander 1975, Lindberg 1975, Odsjö and Sondell 1976).

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Human Health Risk Assessment and Risk Perception Related to the Baltic Seafish should comprise all these compounds. However, toxicological information on many of the polyhalogenated compounds are very limited. This overview will thus cover only polychlorinated dioxins (PCDDs), dibenzofurans (PCDFs) as well as the polychlorinated biphenyls (PCBs). There are 75 PCDDs, 135 P

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Test Methods for Contact Sensitizations the first test which was included in a guideline (Draize 1959). The test was designed to screen out potent sensitizers. Negative results with known human sensitizers, such as benzocaine, neomycin or nickel sulfate (Magnusson and Kligman 1969) were the main reasons to develop other protocols.

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Newer Approaches to the Evaluation of Sensitization Phenomenaly in two stages. Following first encounter with the inducing allergen the susceptible individual mounts a specific immune response which results in sensitization. Subsequent exposure to the same allergen provokes an accelerated and more aggressive response which in turn causes adverse health effect

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Risk Assessment of Sensitizing Agentsfacturer of a variety of consumer and health care products that come in contact with the skin, one of our primary responsibilities to the consumer and our workers is to ensure that our products will not cause allergic contact sensitization. Product and ingredient safety testing should consider all t

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Nuclear retinoic acid receptors and regulation of gene expressionpectrum of effects exerted by retinoids is still poorly understood. However, the discovery in recent years of multiple retinoid nuclear receptors that act as transcriptional trans-regulators, and the diversity of response elements to which they bind to regulate the transcriptional activity of specif