Titlebook: Use of Mechanistic Information in Risk Assessment; Proceedings of the 1 Hermann M. Bolt,Björn Hellman,Lennart Dencker Conference proceeding

CAMEO

The Role of Retinoids in Normal Development and Retinoid-Induced Malformationsin A in visual function in the vertebrate retina. The natural retinoids are isoprenoid compounds with a six-membered carbocyclic ring and an eleven-carbon side chain (Fig. 1), although many of the synthetic compounds with biological retinoid activity differ somewhat from this basic plan (Sporn and R

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Retinoid Teratogenesis: Toxicokinetics and Structure-Specificityfect in a particular target organ is strictly dependent on the concentration-time relationships of the drug and/or its active metabolite(s) in the target tissue, reactive metabolites formed or specific binding phenomena (Monro, 1992). Thus, an effect is dependent on the chemical structure of the xen

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Fortuitous

Risk Estimation and Primary Prevention of Birth Defectsossible effects of substances on the reproductive process, i.e. on sexual organs and its functions, endocrine regulation, fertilization, transport of the fertilized ovum, implantation, and embryonic, foetal and postnatal development, until the end-differentiation of the organs is achieved. Reproduct

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Conference proceedings 1994the world‘s oceans but nevertheless, unique in many ways. The Baltic Sea is the largest area of brackish water in the world. As a formation of nature, it is a sea that in many ways resembles a lake. This makes its flora and fauna interesting and well adapted to the brackish water environment. The re

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cocoon

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Newer Approaches to the Evaluation of Sensitization Phenomenaensitization. Subsequent exposure to the same allergen provokes an accelerated and more aggressive response which in turn causes adverse health effects; the most common of which in the context of industrial toxicology and occupational medicine are allergic contact dermatitis and respiratory hypersensitivity.

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Nuclear retinoic acid receptors and regulation of gene expression act as transcriptional trans-regulators, and the diversity of response elements to which they bind to regulate the transcriptional activity of specific sets of target genes, represents a great advance in our understanding of the mechanisms underlying the complexity of retinoid effects.