Titlebook: Systems Pharmacology and Pharmacodynamics; Donald E. Mager,Holly H.C. Kimko Book 2016 American Association of Pharmaceutical Scientists 20

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Feedback Control Indirect Response Modelslatory mechanisms are incomplete representations of the drug-response relationship, and may lead to an underestimation of a drug’s potency. In this chapter, a new general framework is introduced for modeling pharmacodynamic processes that are subject to autoregulation, in which the canonical IDR mod

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Detecting Pharmacokinetic and Pharmacodynamic Covariates from High-Dimensional Data during pharmacogenetic/genomic clinical trials, there is need for computationally efficient methodologies capable of integrating that information into the drug development pipeline; however, the computational cost of identifying covariates and interactions through traditional parametric statistical

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Multi-scale Modeling of Drug Action in the Nervous Systemeclinical animal models for diseases like schizophrenia, Alzheimer’s disease, and depression. In addition, treatment of patients in real-life situations is far from perfect, and polypharmacy is attempted without a rational understanding of the interactions of the various drugs with each other and wi

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Direct, Indirect, and Signal Transduction Response Modelingcs and response. When relevant, alternative parameterizations and parameter identifiability are discussed. Only the simplest forms of models are provided with some guidelines on how to build more complex models based on a systems pharmacology approach.

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Mehdi Bouhaddou,Marc R. Birtwistled of the special characteristics of computers, their programming, and their potential interactions into systems. In particular, students with specializations other than control systems are not being exposed to the breadth of the considerations needed in control systems engineering, perhaps because i