| 书目名称 | Systems Pharmacology and Pharmacodynamics |
| 编辑 | Donald E. Mager,Holly H.C. Kimko |
| 视频video | |
| 概述 | First book that covers the expertise from systems biology and pharmacodynamics researchers in one place.Outlines how systems pharmacology should reduce the high attrition in the drug development pipel |
| 丛书名称 | AAPS Advances in the Pharmaceutical Sciences Series |
| 图书封面 |  |
| 描述 | While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation. |
| 出版日期 | Book 2016 |
| 关键词 | PK/PD; bioinformatics; drug targets; modeling; pharmacokinetics; systems biology |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-44534-2 |
| isbn_softcover | 978-3-319-83074-2 |
| isbn_ebook | 978-3-319-44534-2Series ISSN 2210-7371 Series E-ISSN 2210-738X |
| issn_series | 2210-7371 |
| copyright | American Association of Pharmaceutical Scientists 2016 |
发表于 2025-3-21 18:15:01
