Titlebook: Systems Pharmacology and Pharmacodynamics; Donald E. Mager,Holly H.C. Kimko Book 2016 American Association of Pharmaceutical Scientists 20

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AAPS Advances in the Pharmaceutical Sciences Serieshttp://image.papertrans.cn/t/image/884914.jpg

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https://doi.org/10.1007/978-3-319-44534-2PK/PD; bioinformatics; drug targets; modeling; pharmacokinetics; systems biology

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brassy

Book 2016le optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and

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2210-7371 ould reduce the high attrition in the drug development pipelWhile systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipli

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Multi-scale Modeling of Drug Action in the Nervous Systeml neurosciences to which very specific neuropharmacology processes are added. This chapter illustrates a multi-scale drug action model for CNS diseases. We show various applications of this platform in actual CNS research and development projects.

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Mechanistic Modeling of Inflammationn (mechanistic) disease and pharmacology models as we move towards more integrated systems pharmacology approaches with the ultimate goal of designing relevant in silico clinical trials enabling rational extrapolation of bench observations.