Titlebook: Systems Biology in Cancer Research and Drug Discovery; Asfar S. Azmi Book 2012 Springer Science+Business Media Dordrecht 2012 Anti-Cancer

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Book 2012egrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers esp

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The Principle of Rational Design of Drug Combination and Personalized Therapy Based on Network Pharmd disease phenotype, is the key “battle map” for rational drug combinations and design of personalized therapy. We also tentatively outline several aspects of the process which might help drive innovation in network construction and shape the future development of network pharmacology applications.

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System Biology Approach to Study Cancer Related Pathwayselling methods together with parameter estimation approaches are used to simulate the dynamic features of biological pathways. The core regulation part of the p53 pathway is analysed as an example, where its network motifs are identified by model selection methods based on the observation of experim

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Modeling Oncogenic Signaling Networks from Gene Expression Dynamicses, termed oncogenes, and inactivation of key tumor suppressor genes. Based on this research, much progress has been made to develop anti-cancer drugs that target the protein products of well-studied oncogenes. However, despite targeted treatment advances, targeted therapies often fail in patients d

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Protein Microarray: An Ideal Platform for Systems Biologyex diseases, such as cancer, diabetes, obesity, mental disorders and .. The major driving forces of systems biology are high-throughput “-omics” technologies, ., genomics, transcriptomics, proteomics and metabolomics and .. Featured as high-throughput, miniaturized and capable of parallel analyses,

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Systems Biology of Pancreatic Cancer: The Role of Tumor-Microenvironment Communication in Developmenlignancy-related death in Western countries and the annual death rate due to this disease approximates its annual incidence rate, which is estimated to be ∼10 cases per 100,000 population. Although there have been some advancements in surgical techniques and adjuvant therapeutic regimens, the surviv

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Understanding Cancer Progression Using Protein Interaction Networkser tissues. Understanding cancer progression requires a profound knowledge of the pathways involved in the communication between proteins and genes at a systems level. Consequently, protein-protein interaction networks play an important role in delineating cancer related pathways. Our understanding