Titlebook: Systems Biology; The Challenge of Com Shigetada Nakanishi,Ryoichiro Kageyama,Dai Watanab Conference proceedings 2009 Springer-Verlag Tokyo

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Dynamic Model of the Basal Ganglia Functions and Movement Disorders neurons containing enkephalin and projects polysynaptically to the GPi/SNr by way of a sequence of connections involving the external segment of the globus pallidus (GPe) and subthalamic nucleus (STN).

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A Posttranslational Chemical Circadian Oscillator in Cyanobacteriaes or models. For this type of analysis, we have analyzed cyanobacteria as one of the simplest organisms to exhibit circadian rhythms and regular pattern formations with cell differentiation. Here, I summarize a brief history and the current state of molecular, biochemical, and synthetic analysis on

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The Apoptotic Signaling Network Dynamically Interprets the Outputs of Individual Signaling Pathways a common mechanism of cell death in response to many intrinsic and extrinsic cytotoxic cues such as cytokines and DNA damage (Strasser et al., 2000; Zhou and Elledge, 2000). Neighboring cells can also directly induce apoptosis in a target cell by secreting prodeath factors. Although cell death is im

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A Possible Role of Homeostasis Between Monomeric and Filamentous Actin in Filament Nucleation Revealut given the complexity of the molecular interplay, it often remains unclear whether the induced phenotype is a direct or an indirect consequence of individual treatment. Even with the data showing clear morphological phenotypes, the question as to whether individual molecules function locally or gl

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Systems Biology Meets Single-Cell Physiology: Role of a Positive-Feedback Signal Transduction Networes produce several signals that are important for LTD. PF activity produces two messengers within Purkinje cells: diacylglycerol (DAG) and inositol trisphosphate (IP3). DAG is important for LTD induction, via its well-known ability to activate protein kinase C (PKC) [6–8], while IP3 contributes to L

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