Titlebook: Systems Biology; The Challenge of Com Shigetada Nakanishi,Ryoichiro Kageyama,Dai Watanab Conference proceedings 2009 Springer-Verlag Tokyo

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A Posttranslational Chemical Circadian Oscillator in Cyanobacteriak generating biological information in addition to classical analysis on a single gene—function relationship. Periodic temporal (rhythmic) and spatial (morphological) pattern formations are both typical examples of dynamic and complex phenomena widely observed in organisms from bacteria to plants an

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The Apoptotic Signaling Network Dynamically Interprets the Outputs of Individual Signaling Pathways 0; Pawson, 2004). Modulation of total levels of key proteins, as well as their posttranslational states and enzymatic activities, could all potentially act as “molecular signals” that are monitored and interpreted. To understand how complex signal-transduction events control cell responses, these mo

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Specific Features of Transient Ras and Sustained Rap1 Activationpectively, and regulate cell growth and differentiation in PC12 cells (Fig. 1a) (Gotoh et al. 1990; Qiu and Green 1992; Traverse et al. 1992; Vaudry et al. 2002). Transient and sustained ERK activation in PC12 cells depends on transient Ras activation and sustained Rap1 activation, respectively (Fig

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Control and Alteration of Protein Traffic in the Cellf proteins for membrane-bounded compartments or organelles. The known principles of protein traffic are that destination signals are encoded in the transported proteins themselves and that they are decoded by receptors in the target membranes, for example [1]..Mitochondria are two-membrane-bounded o

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Plant Functional Genomics Based on Integration of Metabolomics and Transcriptomics: Toward Plant Sys], . (rice) [2], . (poplar) [3], . (grapevine) [4], and . (sorghum) (http://www.phytozome.net/ sorghum). However, even in ., which is most extensively investigated in terms of gene function, only half the genes have been functionally annotated based on sequence similarity to known genes, and the fun

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Biogenesis and Function Mechanisms of Micro-RNAs and Their Role as Oncogenes and Tumor Suppressorsferentiation, proliferation, and apoptosis by negative regulation of the gene expressions at the posttranscriptional level [1–3]. Currently, more than 800 human miRNAs have been identified and registered in the miRNA database miRBase [4]. Strikingly, 30% of protein-coding transcripts in humans is pr