Titlebook: Systems Biological Approaches in Infectious Diseases; Helena I. Boshoff,Clifton E. Barry Book 2007 Birkhäuser Basel 2007 Anästhesie-Inform

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连系

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Amendment

A subsystems-based approach to the identification of drug targets in bacterial pathogens, The whole process allows for a careful consideration of spectrum, drugability, biological rationale and the metabolic role of the specific target within the context of an integrated circuit within a specific metabolic pathway.

骨

Metabolic control analysis to identify optimal drug targets,gle metabolic pathway in a pathogen with the same pathway in its host to identify uniquely vulnerable steps with the greatest potential for specifically inhibiting flux through the pathogen metabolic pathway. The utility of this methodology is illustrated with the glycolysis in Trypanosomes and with oncogenic signaling.

妨碍

Flatter

Applications of transcriptional profiling in antibiotics discovery and development,tial guidance in the identification of new targets. Microarrays will continue to be a workhorse of anti-infectives discovery programs ranging from efficacy assessments of antibiotics (‘forward pharmacology’) to drug safety evaluations (‘toxicogenomics’).

LUMEN