Titlebook: Systems Biological Approaches in Infectious Diseases; Helena I. Boshoff,Clifton E. Barry Book 2007 Birkhäuser Basel 2007 Anästhesie-Inform

anniversary

HIKE

使纠缠

Systems biology and its impact on anti-infective drug development,biology, a systems approach allows targets to be viewed in a wider context of the entire physiology of the cell, with the potential to identify key susceptible nodes and to predict synergistic effects of blocking multiple pathways. In addition to the holistic perspective provided by systems biology,

胆大

细丝

Picks-Disease

Proteomic profiling of cellular stresses in , reveals cellular networks and assists in elucidating ides the blueprint for all protein-based cellular building blocks, the proteome is highly dynamic. The protein composition is constantly adjusting to facilitate survival, growth, and reproduction in an ever-changing environment. In a quest to understand the regulation of cellular networks in bacteri

向前变椭圆

Elucidating the mode-of-action of compounds from metabolite profiling studies, the last couple of years, and the term metabolome is now often used to describe the complete pool of metabolites associated with an organism at any given time. Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy are the best candidates for comprehensive analysis of the metabolo

美色花钱

A subsystems-based approach to the identification of drug targets in bacterial pathogens, pathways as a unit and is a biochemically-informed approach to target selection. The process involves three stages of analysis; the first stage, selection of the target subsystem, is guided by information about its essentiality and on the predicted vulnerability of the targeted pathway or enzyme to

坚毅

阻挡