Titlebook: Systemic Sclerosis; Kazuhiko Takehara,Manabu Fujimoto,Masataka Kuwana Book 2016 Springer Japan 2016 Autoimmune disease.Cytokine.Fibrosis.I

etiquette

Endothelin,scular endothelial cells, vascular smooth muscle cells, fibroblasts, and macrophages/immune cells. Experimental and clinical studies have highlighted the involvement of ET-1 in the pathogenesis of pulmonary arterial hypertension, vasculopathy, and fibrosis of the skin, lungs, and other organs in sys

小步走路

Adjourn

Fli1,ences. Fli1, a member of Ets transcription factor family, is constitutively suppressed in various cell types in the lesional and non-lesional skin of SSc patients at least partially by an epigenetic mechanism. Therefore, Fli1 deficiency is a potential predisposing factor of SSc reflecting environmen

形容词

Nebulizer

斑驳

Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis,of IL-1α in the pathogenesis of tissue fibrosis in systemic sclerosis, and we are currently interested in the roles of IL-33 as well as IL-1α. Herein, I review the involvement of both of these molecules in systemic sclerosis.

SHRIK

乳白光

Endothelin,temic sclerosis as well as the potential therapeutic role for endothelin antagonists in these conditions in systemic sclerosis. This chapter reviews the current knowledge of the endothelin/endothelin receptor system and focuses on the effects of ET-1 and its antagonism on vasculopathy and fibrosis in systemic sclerosis.

本能

enflame

Genetics of Systemic Sclerosis,e. Thus, something must be missing, and more studies are required to reveal the secrets of this enigmatic disease. Here, we reviewed the genetic studies of SSc, with emphasis on those performed on Asian populations.