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Titlebook: Systemic Sclerosis; Kazuhiko Takehara,Manabu Fujimoto,Masataka Kuwana Book 2016 Springer Japan 2016 Autoimmune disease.Cytokine.Fibrosis.I

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发表于 2025-3-21 17:29:55 | 显示全部楼层 |阅读模式
书目名称Systemic Sclerosis
编辑Kazuhiko Takehara,Manabu Fujimoto,Masataka Kuwana
视频video
概述Provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma).Presents a variety of new evidence suggestive of the pathogenesis of scleroderma.Covers clini
图书封面Titlebook: Systemic Sclerosis;  Kazuhiko Takehara,Manabu Fujimoto,Masataka Kuwana Book 2016 Springer Japan 2016 Autoimmune disease.Cytokine.Fibrosis.I
描述This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.
出版日期Book 2016
关键词Autoimmune disease; Cytokine; Fibrosis; Immune activation; Scleroderma; Vasculopathy
版次1
doihttps://doi.org/10.1007/978-4-431-55708-1
isbn_softcover978-4-431-56680-9
isbn_ebook978-4-431-55708-1
copyrightSpringer Japan 2016
The information of publication is updating

书目名称Systemic Sclerosis影响因子(影响力)




书目名称Systemic Sclerosis影响因子(影响力)学科排名




书目名称Systemic Sclerosis网络公开度




书目名称Systemic Sclerosis网络公开度学科排名




书目名称Systemic Sclerosis被引频次




书目名称Systemic Sclerosis被引频次学科排名




书目名称Systemic Sclerosis年度引用




书目名称Systemic Sclerosis年度引用学科排名




书目名称Systemic Sclerosis读者反馈




书目名称Systemic Sclerosis读者反馈学科排名




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发表于 2025-3-21 23:16:19 | 显示全部楼层
Fibrosis: Overview,ed from sclerotic lesions, such as the sclerotic skin or lung, in patients with SSc and cultured in vitro are characterized by increased synthesis of collagen and other extracellular matrix proteins, decreased synthesis and activity of matrix metalloproteinases, and increased synthesis of tissue inh
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Endothelial Progenitor Cells,vascular system is constantly maintained through angiogenesis and vasculogenesis. Endothelial progenitor cells (EPCs), major players of vasculogenesis, are heterogeneous cell population containing an extremely rare number of “true EPCs” and pro-angiogenic hematopoietic cells (PHCs) that promotes vas
发表于 2025-3-22 10:05:12 | 显示全部楼层
Animal Models of Systemic Sclerosis,tracellular matrix proteins in the affected organs. The etiology of scleroderma has not yet been fully elucidated, and thus satisfactory therapeutic drugs are still limited. However, there are two definite and easily available mouse models so far, without genetic modification, tight skin mouse, and
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Interleukin-6 in the Pathogenesis of Systemic Sclerosis,d keratinocytes; and the production of acute-phase proteins such as C-reactive protein (CRP). Many reports suggest that IL-6 plays a partial role in the pathogenesis of systemic sclerosis (SSc). Here, I describe its functions, signal transduction pathways, and involvement in SSc and then introduce a
发表于 2025-3-23 01:36:45 | 显示全部楼层
Epigenetics, and recent researches have suggested that epigenetics play a role by mediating influence of the environmental factors. This chapter discusses the present-day understanding about the abnormalities in epigenetics including methylation, histone modification, and noncoding RNAs in this disease..DNA met
发表于 2025-3-23 09:13:07 | 显示全部楼层
,Transforming Growth Factor-ß and Connective Tissue Growth Factor, heart. Increasing evidence has demonstrated the fundamental role of cytokines in the pathogenesis. Transforming growth factor-β (TGF-β) is a very potent stimulator of collagen synthesis by fibroblasts. While TGF-β has been considered as a primary cytokine involved in the pathogenesis of SSc (LeRoy
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